Continuous compared with cyclic oral contraceptives for the treatment of primary dysmenorrhea: a randomized controlled trial.

Abstract

OBJECTIVE:

To estimate whether continuous oral contraceptive pills (OCPs) will result in more pain relief in primary dysmenorrhea patients than cyclic OCPs, which induce withdrawal bleeding with associated pain and symptoms.

METHODS:

We conducted a double-blind, randomized, controlled trial comparing continuous to a cyclic 21-7 OCP regimen (gestodene 0.075 mg and ethinyl estradiol 20 microgram) for 6 months in 38 primary dysmenorrhea patients. The primary outcome was the difference in subjective perception of pain as measured by the visual analog scale over a period of 6 months.

RESULTS:

Twenty-nine patients completed the study. In both groups, pain reduction measured by visual analog scale declined over time and was significant at 6 months compared with baseline, with no difference between groups. Continuous regimen was superior to cyclic regimen after 1 month (mean difference -27.3, 95% confidence interval [CI] -40.5 to -14.2; P<.001) and 3 months (mean difference -17.8, 95% CI -33.4 to -2.1; P=.03) of treatment. Secondary outcomes noted no difference between groups in terms of menstrual distress as measured by the Moos Menstrual Distress Questionnaire. After 6 months, there was an increase in weight and a decrease in systolic blood pressure in the continuous group compared with the cyclic group.

CONCLUSION:

Both regimens of OCPs are effective in the treatment of primary dysmenorrhea. Continuous OCPs outperform cyclic OCPs in the short term, but this difference is lost after 6 months.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, www.clinicaltrials.gov, NCT00517556.

LEVEL OF EVIDENCE:

I.

• Authors: Romana Dmitrovic, Allen R Kunselman, Richard S Legro
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 119 Issue 6 Pg. 1143-50 (Jun 2012) ISSN: 1873-233X [Electronic] United States
• PMID: 22617578 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)

Chemical References

• Contraceptives, Oral
• Norpregnenes
• Gestodene
• Ethinyl Estradiol

Topics

• Adolescent
• Adult
• Blood Pressure (drug effects)
• Body Weight (drug effects)
• Contraceptives, Oral (administration & dosage)
• Drug Therapy, Combination
• Dysmenorrhea (drug therapy)
• Ethinyl Estradiol (administration & dosage)
• Female
• Humans
• Norpregnenes (administration & dosage)
• Pain (drug therapy)
• Pain Measurement
• Treatment Outcome
• Young Adult