Duration of QRS complex in resting electrocardiogram is a predictor of sudden cardiac death in men.

Abstract

BACKGROUND:

Previous studies indicate that increased QRS duration in ECG is related to the risk of all-cause death. However, the association of QRS duration with the risk of sudden cardiac death (SCD) is not well documented in large population-based studies. Our aim was to examine the relation of QRS duration with SCD in a population-based sample of men.

METHODS AND RESULTS:

This prospective study was based on a cohort of 2049 men aged 42 to 60 years at baseline with a 19-year follow-up, during which a total of 156 SCDs occurred. As a continuous variable, each 10-ms increase in QRS duration was associated with a 27% higher risk for SCD (relative risk, 1.27; 95% confidence interval, 1.14-1.40; P<0.001). Subjects with QRS duration of >110 ms (highest quintile) had a 2.50-fold risk for SCD (relative risk, 2.50; 95% confidence interval, 1.38-4.55; P=0.002) compared with those with QRS duration of <96 ms (lowest quintile), after adjustment for established key demographic and clinical risk factors (age, alcohol consumption, previous myocardial infarction, smoking, serum low- and high-density lipoprotein cholesterol, C-reactive protein, type 2 diabetes mellitus, body mass index, systolic blood pressure, and cardiorespiratory fitness). In addition to QRS duration, smoking, previous myocardial infarction, type 2 diabetes mellitus, cardiorespiratory fitness, body mass index, systolic blood pressure, and C-reactive protein were independently associated with the risk of SCD.

CONCLUSIONS:

QRS duration is an independent predictor of the risk of SCD and may have utility in estimating SCD risk in the general population.

• Authors: Sudhir Kurl, Timo H Mäkikallio, Pentti Rautaharju, Vesa Kiviniemi, Jari A Laukkanen
• Journal: Circulation (Circulation) Vol. 125 Issue 21 Pg. 2588-94 (May 29 2012) ISSN: 1524-4539 [Electronic] United States
• PMID: 22615341 (Publication Type: Journal Article)

Topics

• Adult
• Cohort Studies
• Death, Sudden, Cardiac (epidemiology)
• Electrocardiography
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Prospective Studies
• Rest (physiology)
• Risk Factors
• Survival Analysis
• Time Factors