Abstract | UNLABELLED: OBJECTIVE: STUDY DESIGN: RESULTS: The mean concentration of activity of HEX 1142.39 pKat/ml, GAL 8.90 pKat/ml, and GLUC 14.06 pKat/ml was significantly higher compared with the concentration of enzyme activity in normal tissue: HEX 267.65 pKat/ml, GAL 3.44 pKat/ml, and GLUC 3.90 pKat/ml. In the serum of cholesteatoma patients, the mean concentration of enzyme activities were as follows: HEX 641.62 pKat/ml, GAL 4.55 pKat/ml, and GLUC 12.80 pKat/ml and were significantly higher compared with the concentration of HEX activity (215.75 pKat/ml), GAL (1.89 pKat/ml), and GLUC (5.51 pKat/ml) in the serum of the healthy control group. In cholesteatoma compared with the normal tissue, there is an increase of the glycoconjugate catabolism due to significantly higher concentration of HEX, GAL, and GLUC activity in cholesteatoma. Cholesteatoma causes systemic reaction due to the increase of HEX, GAL, and GLUC activity in patient serum.
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Authors | Ewa Olszewska, Joanna Jakimowicz-Rudy, Malgorzata Knas, Malgorzata Chilimoniuk, Jan Krzysztof Pietruski, Andrzej Sieskiewicz |
Journal | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
(Otol Neurotol)
Vol. 33
Issue 4
Pg. 596-603
(Jun 2012)
ISSN: 1537-4505 [Electronic] United States |
PMID | 22588235
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- beta-Galactosidase
- Glucuronidase
- beta-N-Acetylhexosaminidases
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Topics |
- Adult
- Cholesteatoma, Middle Ear
(enzymology, etiology)
- Glucuronidase
(blood)
- Humans
- Lysosomes
(enzymology)
- Middle Aged
- Skin
(enzymology)
- beta-Galactosidase
(blood)
- beta-N-Acetylhexosaminidases
(blood)
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