[Study of serological diagnosis in ocular chlamydial infection with IPAZYME].

Abstract

We employed a indirect immunoperoxidase assay (IPAZYME in the evaluation of IgG and IgA antibody for Chlamydia trachomatis in serum samples from 218 patients such as cicatricial trachoma 55 cases, culture-positive adult inclusion conjunctivitis 48 cases and culture-negative conjunctivitis 47 cases, aged people, 68 cases as controls respectively. Frequency of positive IgG antibody showed a significant difference between adult inclusion conjunctivitis or cicatricial trachoma and controls. IgA antibody was positive in 25/48 (52%) in adult inclusion conjunctivitis and in 7/55 (12%) in cicatricial trachoma cases. Serum IgA antibody against Chlamydia trachomatis is of value to be an index of active ocular chlamydial inflammation. The correlation between severity of conjunctival cicatrix or corneal punnus and titers of IgG antibody was also significant.

• Authors: C Ran, K Aoki
• Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases (Kansenshogaku Zasshi) Vol. 64 Issue 10 Pg. 1317-22 (Oct 1990) ISSN: 0387-5911 [Print] Japan
• PMID: 2258647 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Bacterial
• Immunoglobulin A
• Immunoglobulin G

Topics

• Aged
• Antibodies, Bacterial (analysis)
• Chlamydia trachomatis (immunology)
• Conjunctivitis, Inclusion (diagnosis, immunology)
• Humans
• Immunoenzyme Techniques
• Immunoglobulin A (analysis)
• Immunoglobulin G (analysis)
• Trachoma (diagnosis, immunology)