Prediction of genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 in the survival of colorectal cancer receiving chemotherapy in the Chinese population.

Abstract

BACKGROUND/AIMS:

We aimed to detect the distribution of DNA repair genes XRCC1 and XRCC3 genotypes in the survival of colorectal cancer patients receiving chemotherapy in the Chinese population.

METHODOLOGY:

The prospective study was conducted with 432 cases treated with 5-FU and oxaliplatin as first-line chemotherapy. All the patients were followed-up from May 2006 to May 2011 and 168 patients died during follow-up. XRCC1 and XRCC3 genotype polymorphisms were based upon the PCR-CTPP method.

RESULTS:

It was shown that the XRCC1 Arg399Gln and XRCC3 Thr241Met gene polymorphisms were associated with increased death risk of colorectal cancer. Individuals carrying XRCC1 Gln/Gln, Thr/Met and Met/Met genotypes positively associated with 2.78-, 2.86- and 3.0-fold death risk of colorectal cancer. Moreover, the combination of XRCC1 399Gln allele and XRCC3 241Met allele showed a significantly strong association with death risk of colorectal cancer (OR=3.46, 95%CI=1.65- 5.48).

CONCLUSIONS:

This study is first to report that the XRCC1 and XRCC3 gene polymorphisms are useful as a surrogate marker of clinical outcome in colorectal cancer with 5-FU/oxaliplatin combination chemotherapy in the Chinese population.

• Authors: Yang Liu, Haihui Chen, Limin Chen, Chunhong Hu
• Journal: Hepato-gastroenterology (Hepatogastroenterology) Vol. 59 Issue 116 Pg. 977-80 (Jun 2012) ISSN: 0172-6390 [Print] Greece
• PMID: 22580644 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• DNA-Binding Proteins
• Organoplatinum Compounds
• X-ray Repair Cross Complementing Protein 1
• X-ray repair cross complementing protein 3
• XRCC1 protein, human
• Oxaliplatin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (genetics)
• Colorectal Neoplasms (drug therapy, genetics, mortality)
• DNA Repair
• DNA-Binding Proteins (genetics)
• Female
• Fluorouracil (administration & dosage)
• Humans
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage)
• Oxaliplatin
• Polymorphism, Genetic
• Prospective Studies
• X-ray Repair Cross Complementing Protein 1