Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer.

Abstract

BACKGROUND:

To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.

METHODS:

A retrospective review of 52 patients undergoing radiotherapy for head and neck cancers with image guidance based on daily megavoltage CT imaging with helical tomotherapy was performed.

RESULTS:

Mean contralateral parotid dose and the volume of the contralateral parotid receiving 40 Gy or more were compared between radiotherapy plans with significant constraint (SC) of less than 20 Gy on parotid dose (23 patients) and the conventional constraint (CC) of 26 Gy (29 patients). All patients had PTV coverage of at least 95% to the contralateral elective neck nodes. Mean contralateral parotid dose was, respectively, 14.1 Gy and 24.7 Gy for the SC and CC plans (p < 0.0001). The volume of contralateral parotid receiving 40 Gy or more was respectively 5.3% and 18.2% (p < 0.0001)

CONCLUSION:

Tomotherapy for head and neck cancer minimized radiotherapy dose to the contralateral parotid gland in patients undergoing elective node irradiation without sacrificing target coverage.

• Authors: Nam P Nguyen, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Lexie Smith-Raymond, Michelle Stevie, Benjamin Slane, Alexander Chi, Anand Desai, Shane P Krafft, Siyoung Jang, Russ Hamilton, Ulf Karlsson, Dave Abraham
• Journal: BMC cancer (BMC Cancer) Vol. 12 Pg. 175 (May 11 2012) ISSN: 1471-2407 [Electronic] England
• PMID: 22578076 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Head and Neck Neoplasms (diagnostic imaging, pathology, radiotherapy)
• Humans
• Male
• Mandible (radiation effects)
• Middle Aged
• Neoplasm Staging
• Parotid Gland (radiation effects)
• Radiotherapy Dosage
• Radiotherapy, Image-Guided
• Retrospective Studies
• Spinal Cord (radiation effects)
• Tomography, Spiral Computed