Abstract | OBJECTIVE: DESIGN: Retrospective audit. SETTING: Single tertiary neonatal intensive care unit at The Royal Women's Hospital in Australia. PATIENTS: Fifty-eight term newborn infants with moderate-to-severe hypoxic-ischaemic encephalopathy. Forty infants were treated with whole-body hypothermia between February 2001 and May 2010, 16 of whom were enrolled in the Infant Cooling Evaluation ( ICE) trial, and 18 control infants randomised to normothermia in the ICE trial. INTERVENTION: Comparison of simultaneous axillary and rectal temperatures measured between 0 and 84 h post randomisation or induction of cooling. RESULTS: During the initiation of hypothermia (0-<6 h) axillary and rectal temperatures were similar (mean difference rectal-axillary =0.07°C), but with large variability (95% limits of agreement -1.18 to 1.33°C). There was larger variability in measurements between 6 and <72 h in the hypothermic infants (total SD 0.44) than in the normothermic group (total SD 0.24, p<0.001). In the hypothermic infants, the mean difference between the measurements during the rewarming phase (72-<84 h) was -0.19°C (95% limits of agreement -0.95 to 0.57°C). CONCLUSION: As there is wide variability in the difference between axillary and rectal temperatures at all stages of whole-body cooling, our data do not support the use of axillary temperature as a surrogate for core rectal temperature during therapeutic hypothermia.
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Authors | Marc-Antoine Landry, Lex W Doyle, Katherine Lee, Susan E Jacobs |
Journal | Archives of disease in childhood. Fetal and neonatal edition
(Arch Dis Child Fetal Neonatal Ed)
Vol. 98
Issue 1
Pg. F54-8
(Jan 2013)
ISSN: 1468-2052 [Electronic] England |
PMID | 22556207
(Publication Type: Journal Article, Randomized Controlled Trial)
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Topics |
- Axilla
- Body Temperature
- Humans
- Hypothermia, Induced
(methods)
- Hypoxia-Ischemia, Brain
(therapy)
- Infant, Newborn
- Rectum
- Reproducibility of Results
- Retrospective Studies
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