Abstract |
Following the hypothesis that thalamic deep brain stimulation improves ataxia in patients with essential tremor by modulating the cerebello-thalamo-cortical pathway, we examined the joint kinematics of lower limbs during uninterrupted gait in eleven patients who have been treated with bilateral thalamic stimulation for 24.7±20.3 months. Patients were assessed under routine chronic stimulation, supra-therapeutic amplitude, and off stimulation by means of an infrared movement analysis system while walking on a treadmill. Chronic thalamic DBS normalized the highly variable excursion throughout the gait cycle that characterized the subgroup of patients with longest disease duration. Supratherapeutic thalamic DBS amplitude did not reproduce such improvements while, more importantly, it induced ataxic changes of joint excursion. The normalization of kinematic abnormalities argues against the hypothesis of a cerebellar neurodegeneration in ET. Moreover, these results suggest that the beneficial effect of thalamic DBS on ataxic symptoms is limited to a narrow therapeutic window.
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Authors | Alfonso Fasano, Jan Herzog, Jan Raethjen, Franziska E M Rose, Jens Volkmann, Daniela Falk, Günther Deuschl |
Journal | Gait & posture
(Gait Posture)
Vol. 36
Issue 2
Pg. 187-93
(Jun 2012)
ISSN: 1879-2219 [Electronic] England |
PMID | 22555066
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Topics |
- Aged
- Ankle Joint
(physiopathology)
- Biomechanical Phenomena
- Deep Brain Stimulation
- Essential Tremor
(complications, therapy)
- Female
- Gait Ataxia
(complications, physiopathology, therapy)
- Hip Joint
(physiopathology)
- Humans
- Knee Joint
(physiopathology)
- Male
- Middle Aged
- Range of Motion, Articular
- Thalamus
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