Abstract | AIM: MAIN METHODS: KEY FINDINGS: SIGNIFICANCE: Primary hyperlipemias show different patterns of response to statins: in PH LDL reduction appears completely "synthesis inhibition" dependent, while in FCH LDL decrease appears to be synthesis dependent, partially limited by absorption increase. Studying cholesterol metabolism before and after hypolipemic therapy might be useful in identifying the best tailored treatment.
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Authors | Graziana Lupattelli, Donatella Siepi, Stefano De Vuono, Anna Rita Roscini, Federica Crisanti, Domenico Covelli, Matteo Pirro, Elmo Mannarino |
Journal | Life sciences
(Life Sci)
Vol. 90
Issue 21-22
Pg. 846-50
(Jun 06 2012)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 22554491
(Publication Type: Controlled Clinical Trial, Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Cholesterol, LDL
- Heptanoic Acids
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Lipids
- Phytosterols
- Pyrroles
- Sitosterols
- campesterol
- gamma-sitosterol
- Cholesterol
- Atorvastatin
- Simvastatin
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Topics |
- Adult
- Aged
- Atorvastatin
- Cholesterol
(analogs & derivatives, blood)
- Cholesterol, LDL
(blood)
- Female
- Gas Chromatography-Mass Spectrometry
- Heptanoic Acids
(pharmacology)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacology)
- Hypercholesterolemia
(drug therapy)
- Hyperlipidemia, Familial Combined
(drug therapy)
- Hyperlipidemias
(drug therapy)
- Lipids
(blood)
- Male
- Middle Aged
- Phytosterols
(blood)
- Pyrroles
(pharmacology)
- Simvastatin
(pharmacology)
- Sitosterols
(blood)
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