Enhanced expression of c-myc and H-ras oncogenes in Letterer-Siwe disease. A sequential study using colorimetric in situ hybridization.

Abstract

Tissues from two patients with disseminated histiocytosis X (Letterer-Siwe disease) in which histiocytosis X cells exhibited histologic and cytologic features of malignancy were evaluated by in situ hybridization with the use of biotinylated nucleic acid probes to c-myc and H-ras oncogenes. Enhanced expression of these oncogenes was observed in mononucleated and multinucleated cells of histiocytosis X in the terminal proliferative phase but not in the early quiescent phase of Letterer-Siwe disease in both patients. Our findings indicate that deregulation of c-myc and H-ras in histiocytosis X are late events that likely confer a selective growth advantage to histiocytosis X cells.

• Authors: O M Abdelatif, F W Chandler, C G Pantazis, B S McGuire
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 114 Issue 12 Pg. 1254-60 (Dec 1990) ISSN: 0003-9985 [Print] United States
• PMID: 2252422 (Publication Type: Case Reports, Journal Article)

Chemical References

• DNA Probes

Topics

• DNA Probes
• Female
• Gene Expression
• Genes, myc (genetics)
• Genes, ras (genetics)
• Histiocytosis, Langerhans-Cell (genetics)
• Humans
• Infant
• Male
• Nucleic Acid Hybridization
• Proto-Oncogenes (genetics)