The purpose of the present study was to investigate the possibilities of potentiation of the antitumor action of
mannosulfan after its administration together with
insulin. The pharmacokinetics of mannnosulfan were investigated after its administration separately and together with
insulin. Concentrations of
mannosulfan in the plasma were determined by gas chromatography.
Insulin enhanced the rate of absorption of
mannosulfan from the peritoneal cavity and prolonged its elimination from the body. It may be assumed that
insulin enhances not only passage of
mannosulfan from the peritoneal cavity to blood, but also from blood to tissues. Since increased antitumor effectiveness of
mannosulfan was accompanied by its decreased toxicity, it may be concluded that
insulin causes selective cummulation of the
cytostatic only in some tissues, among others, in the
tumor.