[Osteoporosis in liver cirrhosis].

Abstract

Osteoporosis is a common complication of chronic liver disease, especially in the final stages. This entity is more critical in liver transplant recipients, when bone loss accelerates during the immediate postoperative period. The main mechanism involved in the development of osteoporosis in liver disease is deficient bone formation due to the harmful effects of substances such as bilirubin and bile acids or the toxic effect of alcohol or iron on osteoblasts. To prevent and treat osteoporosis, good nutrition and calcium and vitamin D supplementation are required. There are no specific recommendations on drug treatment but bisphosphonates are effective in increasing bone mass in patients with chronic cholestasis and have a good safety profile.

• Authors: Núria Guañabens, Albert Parés
• Journal: Gastroenterologia y hepatologia (Gastroenterol Hepatol) 2012 Jun-Jul Vol. 35 Issue 6 Pg. 411-20 ISSN: 0210-5705 [Print] Spain
• Vernacular Title: Osteoporosis en la cirrosis hepática.
• PMID: 22483016 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier España, S.L. y AEEH y AEG. All rights reserved.

Chemical References

• Bile Acids and Salts
• Bone Density Conservation Agents
• Cytokines
• Estrogens
• Vitamin D
• Bilirubin
• Calcium

Topics

• Bile Acids and Salts (metabolism, pharmacology)
• Bilirubin (metabolism, pharmacology)
• Bone Density Conservation Agents (therapeutic use)
• Calcium (therapeutic use)
• Cells, Cultured (drug effects)
• Cytokines (physiology)
• Estrogens (therapeutic use)
• Female
• Forecasting
• Fractures, Spontaneous (epidemiology, etiology, prevention & control)
• Humans
• Liver Cirrhosis (complications, physiopathology)
• Male
• Osteoblasts (drug effects)
• Osteogenesis (drug effects)
• Osteoporosis (drug therapy, epidemiology, etiology, physiopathology, prevention & control)
• Prevalence
• Vitamin D (therapeutic use)