Abstract | OBJECTIVE: METHODS: RESULTS: The frequency of CD25+ among CD4+ T cells was lower at onset in the study group than in controls but increased significantly after IVIG treatment, relative to controls. The frequency of CD25+ among CD4+ T cells correlated with the frequency of FOXP3+ among CD4+ T cells and interleukin 10 produced by CD25+CD4+ T cells. CONCLUSION: The increase in Treg cells seen with the combination of IVIG and conventional therapy may promote remission in EGPA.
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Authors | Naomi Tsurikisawa, Hiroshi Saito, Chiyako Oshikata, Takahiro Tsuburai, Kazuo Akiyama |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 39
Issue 5
Pg. 1019-25
(May 2012)
ISSN: 0315-162X [Print] Canada |
PMID | 22467925
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Immunoglobulins, Intravenous
- Immunologic Factors
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Topics |
- Adult
- Aged
- Churg-Strauss Syndrome
(drug therapy, immunology)
- Dose-Response Relationship, Immunologic
- Eosinophilic Granuloma
(drug therapy, immunology)
- Female
- Humans
- Immunoglobulins, Intravenous
(administration & dosage)
- Immunologic Factors
(administration & dosage)
- Male
- Middle Aged
- Severity of Illness Index
- T-Lymphocytes, Regulatory
(immunology, pathology)
- Treatment Outcome
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