Effect of Sangu Decoction () on metastatic bone destruction in rats with mammary cancer.

Abstract

OBJECTIVE:

To study and evaluate the effect of Sangu Decoction (SGD, ) on the bone destruction due to mammary cancer metastasis.

METHODS:

Metastasis rat mammary tumor-1 cells were transplanted into the left hind limb tibia of SD rats to establish the bone metastasis of the mammary cancer model. The modeled rats were treated with SGD for observing its effect on rats' pain behavior, including 50% paw withdrawal threshold (50% PWT) after von Frey fiber stimulation, burden difference of bilateral feet, and thermal withdrawal latency (TWL), with zoledronic acid as the positive control. Moreover, the damage in the tibia sample of rats was scored by an iconographic method, and the bone mineral density (BMD) as well as the bone mineral content (BMC) were estimated.

RESULTS:

The model established showed characteristics of mixed metastasis, revealing the manifestations of tumor development, bone destruction, cancerous pain, etc. In the SGD-treated group, 50% PWT was prolonged (8.13 ± 4.76 vs. 2.30 ± 2.19), and TWL was longer (3.48 ± 0.62 s vs. 2.89 ± 0.26 s) than those in the control group, respectively (P<0.05 or P<0.01). Iconographic scoring also showed improvement of BMD (0.134 ± 0.009 vs. 0.120 ± 0.007, P<0.01) and an elevating trend of BMC in the SGD-treated group.

CONCLUSION:

SGD could effectively alleviate the cancerous pain of bone metastasis and mitigate the metastasis that cause osteolytic destruction of bone.

• Authors: Bo Deng, Li-Qun Jia, Fu-Yun Gao, Jian Cui, Huan Li
• Journal: Chinese journal of integrative medicine (Chin J Integr Med) Vol. 18 Issue 4 Pg. 304-7 (Apr 2012) ISSN: 1993-0402 [Electronic] China
• PMID: 22457143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• sangu

Topics

• Animals
• Bone Density (drug effects)
• Bone Neoplasms (drug therapy, physiopathology, secondary)
• Bone and Bones (drug effects, pathology, physiopathology)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Female
• Mammary Neoplasms, Animal (pathology)
• Rats
• Rats, Sprague-Dawley
• Reaction Time (drug effects)