Abstract | OBJECTIVES: METHODS: Patients were classified according to the grading of the World Federation of Neurological Surgeons (WFNS) in low- and high-grade patients (WFNS = 1-3, n = 9 and WFNS = 4-5, n = 12, respectively). Cerebral microdialysis probes were placed in brain parenchyma of the respective vascular territory of the aneurysm in 21 consecutive aSAH patients, enrolled in a prospective study on inflammation. Microdialysis samples, collected daily from day 0 until day 8 after aSAH, were retrospectively analyzed for MMP-9 by zymography. RESULTS: Initial concentration of the MMP-9 proform (pro-MMP-9) was significantly higher in high-grade patients as compared to low-grade patients. Furthermore, initial pro-MMP-9 concentration in patients with DCI was seven-fold higher than in asymptomatic patients. Pro-MMP-9 values greater than or equal to 0·27 pg/μl showed 83% sensitivity and 63% specificity in predicting vasospasm. The mature form of the MMP-9 could be preferentially detected in patients with DCI but was usually low. DISCUSSION: The pro and mature forms of MMP-9 were released locally in the brain after aSAH. Pro-MMP-9 release was related to WFNS grade severity. This protease, considered as playing a critical role in endothelial basal membrane damage, may contribute to the inflammatory processes leading to arterial narrowing.
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Authors | Asita Sarrafzadeh, Jean-Christophe Copin, Daniel Jiménez Bengualid, Natacha Turck, Peter Vajkoczy, Philippe Bijlenga, Karl Schaller, Yvan Gasche |
Journal | Neurological research
(Neurol Res)
Vol. 34
Issue 5
Pg. 455-61
(Jun 2012)
ISSN: 1743-1328 [Electronic] England |
PMID | 22449315
(Publication Type: Journal Article)
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Chemical References |
- Matrix Metalloproteinase 9
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Topics |
- Adult
- Aged
- Cerebral Cortex
(diagnostic imaging, pathology)
- Extracellular Fluid
(enzymology)
- Female
- Humans
- Male
- Matrix Metalloproteinase 9
(metabolism)
- Microdialysis
- Middle Aged
- Prospective Studies
- ROC Curve
- Retrospective Studies
- Subarachnoid Hemorrhage
(diagnostic imaging, enzymology, pathology)
- Tomography, X-Ray Computed
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