Regimens with intraperitoneal cisplatin plus intravenuous cyclophosphamide and intraperitoneal carboplatin plus intravenuous cyclophosphamide are equally effective in second line intraperitoneal chemotherapy for advanced ovarian cancer.

Abstract

PURPOSE:

We compared response, survival and side effects of regiments with intravenous cyclophosphamide followed by intraperitoneal cisplatin versus intravenous cyclophosphamide followed by intraperitoneal carboplatin as second line treatment in one center retrospective study.

MATERIAL AND METHODS:

Inclusion criteria were: relapse or recurrence of the disease after surgery and first line treatment; stage III histologicaly documented serous epithelial ovarian cancer after one or more prior regiments of chemotherapy. Recurrence were confirmed throughout restaging laparotomy or second look laparotomy. Patients from one of the groups received 90 mg/m(2) cisplatin on the first day and 750 mg/m(2) cyclophosphamide intravenously, while the second group members AUC 6 carboplatin intraperitoneally and 750 mg/m(2) cyclophosphamide intravenously. Four courses were administrated for each patient.

RESULTS:

Of the 49 patients in the cisplatin group the response rates were 21 (43%), 10 (20%) and 18 (37%) in the groups of pathologic complete response, pathologic partial response and progressive disease, respectively. The median survival from the initiation of intraperitoneal chemotherapy was 59 months. Of the 25 patients in the carboplatin group the response rates were 10 (40%), 4 (16%) and 11 (44%) respectively. The median survival -51 months. The differences between the groups were not statistically significant p>0.05 either in response or in toxicity.

CONCLUSIONS:

The results of our research including relatively long survival from intraperotoneal chemotherapy initiation confirm that carboplatin treatment is as good as cisplatin in second line intraperitoneal chemotherapy for ovarian cancer.

• Authors: T Milczek, D Klasa-Mazurkiewicz, J Sznurkowski, J Emerich
• Journal: Advances in medical sciences (Adv Med Sci) Vol. 57 Issue 1 Pg. 46-50 (Jun 01 2012) ISSN: 1898-4002 [Electronic] Netherlands
• PMID: 22430042 (Publication Type: Journal Article)

Chemical References

• Cyclophosphamide
• Carboplatin
• Cisplatin

Topics

• Adult
• Aged
• Carboplatin (administration & dosage, therapeutic use)
• Carcinoma, Ovarian Epithelial
• Cisplatin (administration & dosage, therapeutic use)
• Cyclophosphamide (administration & dosage, therapeutic use)
• Female
• Humans
• Middle Aged
• Neoplasms, Glandular and Epithelial (drug therapy)
• Ovarian Neoplasms (drug therapy)
• Treatment Outcome
• Young Adult