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Bystander-mediated stimulation of proteolipid protein-specific regulatory T (Treg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-β.

Abstract
To assess the potency of regulatory T (Treg) cells induced against an irrelevant Ag, mice were orally vaccinated with Salmonella expressing Escherichia coli colonization factor antigen I fimbriae. Isolated CD25⁺ and CD25⁻CD4⁺ T cells were adoptively transferred to naive mice, and Treg cells effectively protected against experimental autoimmune encephalomyelitis (EAE), unlike Treg cells from Salmonella vector-immunized mice. This protection was abrogated upon in vivo neutralization of TGF-β, resulting in elevated IL-17 and loss of IL-4 and IL-10 production. Thus, Treg cells induced to irrelevant Ags offer a novel approach to treat autoimmune diseases independent of auto-Ag.
AuthorsSangmu Jun, Javier Ochoa-Repáraz, Dagmara Zlotkowska, Teri Hoyt, David W Pascual
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 245 Issue 1-2 Pg. 39-47 (Apr 2012) ISSN: 1872-8421 [Electronic] Netherlands
PMID22418032 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Epitopes, T-Lymphocyte
  • Interleukin-17
  • Myelin Proteolipid Protein
  • Plp1 protein, mouse
  • Transforming Growth Factor beta
  • Interleukin-10
  • Interleukin-4
Topics
  • Adoptive Transfer (methods)
  • Animals
  • Bystander Effect (immunology)
  • Disease Models, Animal
  • Down-Regulation (immunology)
  • Encephalomyelitis, Autoimmune, Experimental (immunology, pathology, therapy)
  • Epitopes, T-Lymphocyte (immunology)
  • Female
  • Interleukin-10 (antagonists & inhibitors, biosynthesis)
  • Interleukin-17 (biosynthesis, physiology)
  • Interleukin-4 (antagonists & inhibitors, biosynthesis)
  • Mice
  • Mice, Inbred Strains
  • Myelin Proteolipid Protein (immunology)
  • Primary Cell Culture
  • T-Lymphocytes, Regulatory (immunology, metabolism, transplantation)
  • Transforming Growth Factor beta (antagonists & inhibitors, physiology)

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