Head circumference in untreated and IGF-I treated patients with Laron syndrome: comparison with untreated and hGH-treated children with isolated growth hormone deficiency.

Abstract

BACKGROUND:

Head circumference (HC) is a simple and practical measure of brain size, development and longitudinal measurements of the HC in childhood are an index of brain growth.

OBJECTIVE:

To determine the effects of long IGF-I deficiency and treatment on HC in patients with Laron syndrome (LS).

PATIENTS:

20 untreated adult LS patients, aged 48.4±11.2 years and 13 LS patients treated between ages of 5.6±4 to 11.3±3 years were studied. 15 patients with congenital IGHD treated between age 6.1±4 and 13±4 by hGH served as controls.

METHODS:

HC was expressed as standard deviation (SD) and Ht as SDS. HC was measured and plotted on Nellhaus charts. Linear height (Ht) was measured by a Harpenden Stadiometer.

CONCLUSIONS:

The mean HC deficit of the adult untreated LS males was -2.9±0.6 SD compared to a Ht deficit of -7.0±1.7 SDS. The HC of the LS adult females was -3.6±1 SD compared to a Ht SDS of -6.9±1.5 (p<0.001). IGF-I treatment (150-200 μg/kg once daily) increased the HC from -3.3±0.9 (m±SD) to normal values (0.87±1.8 SD) (p<0.001) in 11/13 children. The Ht SDS deficit decreased only by 1.5 SDS. hGH treatment of cIGHD children increased the HC from -2.0±1.8 to 0.3±1.2 SD and the Ht SDS from -4.8±1.6 to 1.6±1.0.

• Authors: Zvi Laron, Moshe Iluz, Rivka Kauli
• Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (Growth Horm IGF Res) Vol. 22 Issue 2 Pg. 49-52 (Apr 2012) ISSN: 1532-2238 [Electronic] Scotland
• PMID: 22414926 (Publication Type: Comparative Study, Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Human Growth Hormone
• Insulin-Like Growth Factor I
• Growth Hormone

Topics

• Adolescent
• Adult
• Brain (physiology)
• Case-Control Studies
• Cephalometry
• Child
• Child, Preschool
• Dwarfism, Pituitary (drug therapy)
• Female
• Growth Hormone (deficiency)
• Head (physiology)
• Human Growth Hormone (metabolism)
• Humans
• Insulin-Like Growth Factor I (metabolism)
• Laron Syndrome (drug therapy, physiopathology)
• Male
• Middle Aged