Effects of add-on therapy with NDC-052, an extract from Magnoliae Flos, in adult asthmatic patients receiving inhaled corticosteroids.

Abstract

BACKGROUND/AIMS:

There is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use, was recently found to have anti-inflammatory effects. Herein, we evaluated the effects of NDC-052 as an add-on therapy in patients with mild to moderate asthma using inhaled corticosteroids (ICS).

METHODS:

In a non-comparative, multi-center trial, 148 patients taking ICS received NDC-052 for eight weeks. We evaluated their forced expiratory volume in one second (FEV1), morning and evening peak expiratory flow rate (AM and PM PEFR), AM/PM asthma symptom scores, visual analogue symptom (VAS) scores, night-time wakening, frequency of short-acting β2-agonist usage, and adverse events.

RESULTS:

After eight weeks, both AM and PM PEFRs were significantly improved. Asthma symptom scores, VAS scores, the frequency of nights without awakening, and the frequency of β2-agonist use were also reduced. Most of the adverse drug reactions were mild and resolved spontaneously.

CONCLUSIONS:

The addition of NDC-052 to ICS had a beneficial effect on asthma control in patients with mild to moderate asthma, with good tolerability and fewer side effects. Further studies are necessary to evaluate the effects of NDC-052 in patients with severe and/or refractory asthma.

• Authors: Chan Sun Park, Tae-Bum Kim, Jae-Young Lee, Jae Yong Park, Yong Chul Lee, Seong Su Jeong, Yang Deok Lee, You Sook Cho, Hee-Bom Moon
• Journal: The Korean journal of internal medicine (Korean J Intern Med) Vol. 27 Issue 1 Pg. 84-90 (Mar 2012) ISSN: 2005-6648 [Electronic] Korea (South)
• PMID: 22403504 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenal Cortex Hormones
• Adrenergic beta-2 Receptor Agonists
• Anti-Asthmatic Agents
• Drugs, Chinese Herbal
• NDC-052

Topics

• Administration, Inhalation
• Adrenal Cortex Hormones (administration & dosage)
• Adrenergic beta-2 Receptor Agonists (therapeutic use)
• Adult
• Anti-Asthmatic Agents (administration & dosage, therapeutic use)
• Asthma (diagnosis, drug therapy, physiopathology)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Forced Expiratory Volume
• Humans
• Lung (drug effects, physiopathology)
• Magnolia
• Male
• Middle Aged
• Peak Expiratory Flow Rate
• Prospective Studies
• Republic of Korea
• Severity of Illness Index
• Time Factors
• Treatment Outcome