Abstract | OBJECTIVES:
Linezolid may be an effective treatment for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). The objective was to evaluate the efficacy, tolerability and adverse events of a 300 mg daily dose of linezolid in the treatment of MDR/ XDR-TB. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 51 MDR-TB patients, including 26 patients (51%) with XDR-TB, to evaluate the safety, tolerability and efficacy of therapy with 300 mg/day linezolid. All patients had failed previous treatments with second-line anti-TB drugs. RESULTS: Patients were treated with linezolid for a median of 413 days (IQR 237-622 days). Favourable treatment outcome (treatment success or still on treatment after culture conversion) was achieved in 40 patients (78%) with culture conversion at a median of 55 days (IQR 41-91 days) from the start of linezolid therapy. Eleven patients (22%) had unfavourable outcomes (treatment failure or death) and 14 (27%) discontinued treatment due to neurotoxicity (peripheral or optic neuropathy) after a median of 278 days (IQR 174-412 days). CONCLUSIONS: Our findings suggest that linezolid at a daily dose of 300 mg is effective against intractable MDR/ XDR-TB, and may be associated with fewer neuropathic side effects than a daily dose of 600 or 1200 mg.
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Authors | Won-Jung Koh, Yeh Rim Kang, Kyeonman Jeon, O Jung Kwon, Jiwon Lyu, Woo Sung Kim, Tae Sun Shim |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 67
Issue 6
Pg. 1503-7
(Jun 2012)
ISSN: 1460-2091 [Electronic] England |
PMID | 22403262
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetamides
- Antitubercular Agents
- Oxazolidinones
- Linezolid
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Topics |
- Acetamides
(administration & dosage, adverse effects)
- Adult
- Antitubercular Agents
(administration & dosage, adverse effects)
- Female
- Humans
- Linezolid
- Male
- Middle Aged
- Oxazolidinones
(administration & dosage, adverse effects)
- Retrospective Studies
- Treatment Outcome
- Tuberculosis, Multidrug-Resistant
(drug therapy)
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