Induction of type I interferon by high-molecular poly-γ-glutamate protects B6.A2G-Mx1 mice against influenza A virus.

Abstract

In addition to development of vaccines and synthetic antiviral drugs, recent studies have advocated the use of natural substances that inhibit or prevent viral infections. High-molecular-weight poly-γ-glutamate (HM-γ-PGA) produced by Bacillus subtilis chungkookjang was evaluated for anti-influenza virus activity. HM-γ-PGA induced type I interferons (IFNs), which in turn stimulated expression of Myxovirus resistant 1 protein and IFN-related proteins in vitro. In the B6.A2G-Mx1 mouse model, which mimics the innate immune system of humans, treatment with HM-γ-PGA enhanced the antiviral state of mice and protected them against highly pathogenic influenza A virus. Naturally synthesized HM-γ-PGA has potent anti-influenza activity and may be a useful means for control of influenza virus.

• Authors: Ho-Jin Moon, Jong-Soo Lee, Young-Ki Choi, Jie-Yeun Park, Melbourne R Talactac, Mohammed Y E Chowdhury, Haryoung Poo, Moon-Hee Sung, Ji-Hoon Lee, Jae U Jung, Chul-Joong Kim
• Journal: Antiviral research (Antiviral Res) Vol. 94 Issue 1 Pg. 98-102 (Apr 2012) ISSN: 1872-9096 [Electronic] Netherlands
• PMID: 22401806 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Antiviral Agents
• Interferon Type I
• Mx1 protein, mouse
• Myxovirus Resistance Proteins
• poly(gamma-glutamic acid)
• Polyglutamic Acid
• GTP-Binding Proteins

Topics

• Animals
• Antiviral Agents (administration & dosage, chemistry)
• GTP-Binding Proteins (genetics, immunology)
• Humans
• Influenza A virus (drug effects, physiology)
• Influenza, Human (drug therapy, immunology, prevention & control, virology)
• Interferon Type I (immunology)
• Mice
• Mice, Transgenic
• Molecular Weight
• Myxovirus Resistance Proteins
• Polyglutamic Acid (administration & dosage, analogs & derivatives, chemistry)