Tumor markers panel and tumor size of ovarian dermoid tumors in reproductive age.

Abstract

OBJECTIVE:

To study whether there is any relationship between a serum tumor markers panel (CA19-9, CA 125, CEA, CA15-3 and AFP) and the tumor size in patients with ovarian dermoid cyst in reproductive age.

BACKGROUND:

Between January 2006-2007, 160 patients were operated in the Department of Infertility, Zekai Tahir Burak Women Health Hospital due to ovarian dermoid cyst.

METHODS:

The clinical data and serum tumor markers levels of operated patients were retrieved from the records of the department. This was a retrospective study.

RESULTS:

Forty-four patients (37.6 %) had high levels of CA 19-9 , twenty-seven patients (19.3 %) had high CA 125 levels, eleven patients (9.4 %) had high levels of CEA, five patients (4 %) had high levels of CA 15-3 and one patient (0.9 %) had high AFP levels at the time of initial surgery. The bilaterality rate was 8.1 %. When grouping the tumor size as 10 cm, the mean serum levels of tumor markers had significantly increased by increasing the tumor size (p<0.05) for CA 19-9, CA 125, CEA.

CONCLUSIONS:

Our study suggests that serum CA 19-9 is probably more accurate marker than other tumor markers in the ovarian dermoid cysts. Also, the most important parameter that affects CA 19-9 elevation in the dermoid cysts, is the tumor size. As the tumor becomes bigger, this relationship becomes more distinct (Tab. 2, Ref. 15).

• Authors: T Var, E A Tonguc, M Ugur, S Altinbas, A Tokmak
• Journal: Bratislavske lekarske listy (Bratisl Lek Listy) Vol. 113 Issue 2 Pg. 95-8 ( 2012) ISSN: 0006-9248 [Print] Slovakia
• PMID: 22394039 (Publication Type: Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• Carcinoembryonic Antigen
• alpha-Fetoproteins

Topics

• Adolescent
• Adult
• Antigens, Tumor-Associated, Carbohydrate (analysis)
• Biomarkers, Tumor (analysis)
• Carcinoembryonic Antigen (analysis)
• Dermoid Cyst (diagnosis, pathology)
• Female
• Humans
• Ovarian Neoplasms (diagnosis, pathology)
• Young Adult
• alpha-Fetoproteins (analysis)