Association between endometriosis and polymorphisms in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptor and osteoprotegerin genes and their serum levels.

Abstract

PURPOSE:

To evaluate the relationship between endometriosis and polymorphisms in the genes encoding tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), TRAIL receptor (DR) and osteoprotegerin (OPG) and their serum levels in Korean women.

METHODS:

A case-control study was conducted with 138 women with endometriosis and 214 women without endometriosis in academic medical center. TRAIL c.49G>A, c.592A>G, c.615A>G, and c.662T>C; DR4 c.626G>C and c.1322A>G; DR5 c.95C>T, c.200C>T, and c.72T>G; OPG -245T>G, c.9C>G, c.788A>C, and c.9938G>T polymorphisms were investigated and circulating levels of TRAIL and OPG were measured.

RESULTS:

The TRAIL c.49G>A, c.615A>G, and c.662T>C; the DR4 c.626G>C; the DR5 c.72T>G; the OPG c.788A>C and c.9938G>T polymorphisms were not observed. The genotype distributions and allele frequencies of single or combined polymorphisms of TRAIL, DR4, DR5, and OPG measured in women with endometriosis were not different from those in women without endometriosis, regardless of endometriosis stage. Serum TRAIL and OPG levels were significantly lower in women with endometriosis than in women without endometriosis, but these levels did not show differences between early and advanced endometriosis.

CONCLUSIONS:

Endometriosis is associated with circulating TRAIL and OPG levels in Korean women but not with the TRAIL, DR, and OPG polymorphisms.

• Authors: Hoon Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim, Jong Hak Kim, Jung Gu Kim
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 286 Issue 1 Pg. 147-53 (Jul 2012) ISSN: 1432-0711 [Electronic] Germany
• PMID: 22392486 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Osteoprotegerin
• Receptors, TNF-Related Apoptosis-Inducing Ligand
• TNF-Related Apoptosis-Inducing Ligand

Topics

• Adult
• Asian People (genetics)
• Case-Control Studies
• Endometriosis (blood, genetics)
• Female
• Gene Frequency
• Genotype
• Humans
• Osteoprotegerin (blood, genetics)
• Polymorphism, Single Nucleotide
• Receptors, TNF-Related Apoptosis-Inducing Ligand (blood, genetics)
• Republic of Korea
• TNF-Related Apoptosis-Inducing Ligand (blood, genetics)
• Young Adult