Abstract | BACKGROUND: OBJECTIVES: The objective of this study was to evaluate the thickness of the paramacular retina, peripapillary retinal nerve fibre layer, and deeper paramacular layers in MS patient subgroups, using state-of-the-art optical coherence tomography. METHODS: Using a Heidelberg Engineering Spectralis device, we performed paramacular volumetric retinal scans and circular peripapillary fibre-layer scans, manually segmenting different retinal layers into single horizontal foveal scans in 95 patients with definite MS (42 relapsing-remitting, 41 secondary progressive, 12 primary progressive), plus 91 age- and sex-matched controls. RESULTS: Even without a history of optic neuritis, all MS subgroups had significant thinning of the peripapillary retinal nerve fibre layer, the paramacular retinal thickness and the retinal ganglion cell- and inner plexiform layer. Only in primary progressive MS was the inner nuclear layer significantly reduced. CONCLUSIONS:
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Authors | P Albrecht, M Ringelstein, A K Müller, N Keser, T Dietlein, A Lappas, A Foerster, H P Hartung, O Aktas, A Methner |
Journal | Multiple sclerosis (Houndmills, Basingstoke, England)
(Mult Scler)
Vol. 18
Issue 10
Pg. 1422-9
(Oct 2012)
ISSN: 1477-0970 [Electronic] England |
PMID | 22389411
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Female
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
(complications, pathology)
- Retina
(pathology)
- Tomography, Optical Coherence
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