Abstract | BACKGROUND: METHODS: NASH was induced in male N-Mary rats by feeding a methionine - choline deficient (MCD) diet. The rats were fed either normal chow or MCD diet for 10 weeks. After NASH development, the MCD-fed rats were randomly divided into four groups of six: the NASH group that received MCD diet, the EUK-8 group which was fed MCD diet plus EUK-8, the EUK-134 group which was fed MCD diet plus EUK-134 and the vitamin C group which received MCD diet plus vitamin C. EUK-8, EUK-134 and vitamin C (30 mg/kg body weight/day) were administered by gavage for eight weeks. RESULTS: CONCLUSION:
Antioxidant ( EUK-8, EUK-134 and vitamin C) supplementation reduces NASH-induced biochemical and histological abnormalities, pointing out that antioxidant strategy could be beneficial in treatment of NASH.
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Authors | Alireza Rezazadeh, Razieh Yazdanparast, Mahsa Molaei |
Journal | Journal of biomedical science
(J Biomed Sci)
Vol. 19
Pg. 26
(Feb 29 2012)
ISSN: 1423-0127 [Electronic] England |
PMID | 22375551
(Publication Type: Journal Article)
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Copyright | © 2012 Rezazadeh et al; licensee BioMed Central Ltd. |
Chemical References |
- EUK-134
- Ethylenediamines
- Organometallic Compounds
- Salicylates
- N,N'-bis(salicylideneamino)ethane-manganese(II)
- Methionine
- Ascorbic Acid
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Topics |
- Animals
- Ascorbic Acid
(administration & dosage)
- Choline Deficiency
- Diet
- Disease Models, Animal
- Ethylenediamines
(administration & dosage)
- Fatty Liver
(chemically induced, drug therapy)
- Humans
- Lipid Peroxidation
(drug effects)
- Methionine
(deficiency)
- Organometallic Compounds
(administration & dosage)
- Oxidative Stress
(drug effects)
- Rats
- Salicylates
(administration & dosage)
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