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First case of breakthrough pneumonia due to Aspergillus nomius in a patient with acute myeloid leukemia.

Abstract
We report the first known case of a breakthrough pulmonary infection caused by Aspergillus nomius in an acute myeloid leukemia patient receiving caspofungin therapy. The isolate was identified using matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and sequencing-based methods. The organism was found to be fully susceptible, in vitro, to echinocandin antifungal agents.
AuthorsMorena Caira, Brunella Posteraro, Maurizio Sanguinetti, Elena de Carolis, Giuseppe Leone, Livio Pagano
JournalMedical mycology (Med Mycol) Vol. 50 Issue 7 Pg. 746-50 (Oct 2012) ISSN: 1460-2709 [Electronic] England
PMID22369623 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Caspofungin
Topics
  • Aged
  • Antifungal Agents (administration & dosage)
  • Aspergillus (chemistry, classification, genetics, isolation & purification)
  • Caspofungin
  • Echinocandins (administration & dosage)
  • Humans
  • Leukemia, Myeloid, Acute (complications)
  • Lipopeptides
  • Male
  • Microbial Sensitivity Tests
  • Microscopy
  • Mycology (methods)
  • Phylogeny
  • Pulmonary Aspergillosis (diagnosis, microbiology, pathology)
  • Sequence Analysis, DNA
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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