Antimetastasis effect of anthraquinones from marine fungus, Microsporum sp.

Abstract

This chapter discusses about obtaining natural products which have anticancer metastasis activities from selected marine-derived fungus (Microsporum sp.) and investigates their biological activities such as cytotoxicity on viability cell lines, anticancer cell migration and invasion, protease inhibition, and expression of matrix metalloproteinase (MMP-2 and -9). Moreover, the correlative mechanisms behind these activities were studied.

• Authors: Chen Zhang, Se-Kwon Kim
• Journal: Advances in food and nutrition research (Adv Food Nutr Res) Vol. 65 Pg. 415-21 ( 2012) ISSN: 1043-4526 [Print] United States
• PMID: 22361203 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Anthraquinones
• Antineoplastic Agents
• Enzyme Inhibitors
• Matrix Metalloproteinase Inhibitors
• Mycotoxins
• Matrix Metalloproteinases

Topics

• Animals
• Anthraquinones (metabolism, pharmacology, therapeutic use)
• Antineoplastic Agents (metabolism, pharmacology, therapeutic use)
• Aquatic Organisms (metabolism)
• Cell Movement (drug effects)
• Drug Discovery
• Enzyme Inhibitors (metabolism, pharmacology, therapeutic use)
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Matrix Metalloproteinase Inhibitors
• Matrix Metalloproteinases (genetics, metabolism)
• Microsporum (metabolism)
• Mycotoxins (metabolism, pharmacology, therapeutic use)
• Neoplasm Metastasis (prevention & control)