Abstract |
Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults. The J-RBR/J-KDR registry developed by the Japanese Society of Nephrology provides nationwide cohort data for epidemiological studies of MN. MN was present in 36.8% of 1,203 primary nephrotic syndrome patients in Japan. In addition, 633 (77.9%) out of 813 MN patients were referred to as "idiopathic," whereas 22.1% were classified as "secondary" and involved conditions such as systemic lupus erythematosus, drug exposure, infections, cancer, and various collagen diseases. The mean age of the MN patients was 62.2 (2-88) years old, their mean eGFR was 76.7 (7.6-154.6) ml/min/1.73 m(2), and 63.3% had hypertension at the time of renal biopsy. On the basis of these findings, half of Japanese idiopathic MN patients have risk factors (age >60, male, or lower eGFR) for end-stage renal failure, and 10% belong to the high-risk group (daily proteinuria of over 8.0 g). Further studies with high-grade evidence should resolve the natural history and therapeutic problems of idiopathic MN in elderly Japanese.
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Authors | Hitoshi Yokoyama, Takashi Taguchi, Hitoshi Sugiyama, Hiroshi Sato, Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry in the Japanese Society of Nephrology |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 16
Issue 4
Pg. 557-63
(Aug 2012)
ISSN: 1437-7799 [Electronic] Japan |
PMID | 22358611
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biopsy
- Brazil
(epidemiology)
- Child
- Child, Preschool
- Female
- Glomerular Filtration Rate
(physiology)
- Glomerulonephritis, Membranous
(epidemiology, pathology, physiopathology)
- Humans
- Japan
(epidemiology)
- Kidney
(pathology, physiopathology)
- Male
- Middle Aged
- Nephrotic Syndrome
(epidemiology, pathology, physiopathology)
- Registries
- Republic of Korea
(epidemiology)
- United States
(epidemiology)
- Young Adult
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