Abstract | AIM: METHODS: RESULTS: Seventy-five patients treated with ezetimibe monotherapy and 16 patients treated with combined therapy of ezetimibe with different statins completed this study. Following 12 weeks of ezetimibe monotherapy, serum LDL-C, triglyceride, remnant-like particles cholesterol, matrix metalloproteinase-9, insulin, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein, the relative mobility of the peak of the LDL fraction, and cholesterol absorption markers were significantly decreased, and high-density lipoprotein cholesterol and lathosterol were significantly increased. In the combined therapy group, LDL-C and cholesterol absorption markers were significantly decreased after treatment. In patients with a high basal ALT level that were treated with monotherapy, ALT and the AST/ALT ratio were significantly decreased and increased, respectively, after treatment. CONCLUSION:
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Authors | Noboru Tamaki, Hiroaki Ueno, Yuta Morinaga, Tomomi Shiiya, Masamitsu Nakazato |
Journal | Journal of atherosclerosis and thrombosis
(J Atheroscler Thromb)
Vol. 19
Issue 6
Pg. 532-8
( 2012)
ISSN: 1880-3873 [Electronic] Japan |
PMID | 22353686
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Azetidines
- Biomarkers
- Lipids
- Lipoproteins, HDL
- Lipoproteins, LDL
- Vascular Cell Adhesion Molecule-1
- Matrix Metalloproteinase 9
- Ezetimibe
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Topics |
- Administration, Oral
- Anticholesteremic Agents
(administration & dosage)
- Asian People
- Atherosclerosis
(drug therapy, metabolism)
- Azetidines
(administration & dosage)
- Biomarkers
(metabolism)
- Case-Control Studies
- Ezetimibe
- Female
- Humans
- Hypercholesterolemia
(drug therapy, metabolism)
- Inflammation
(drug therapy, metabolism)
- Insulin Resistance
- Lipids
(analysis)
- Lipoproteins, HDL
(metabolism)
- Lipoproteins, LDL
(metabolism)
- Liver Diseases
(drug therapy, metabolism)
- Male
- Matrix Metalloproteinase 9
(metabolism)
- Middle Aged
- Prognosis
- Prospective Studies
- Vascular Cell Adhesion Molecule-1
(metabolism)
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