Association analysis of genetic variants in microRNA networks and gastric cancer risk in a Chinese Han population.
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| Abstract | PURPOSE: To investigate associations between genetic variants involved in microRNA networks (microRNA biogenesis, microRNA and microRNA binding sites) and risk of gastric cancer. METHODS: We genotyped 19 SNPs of the microRNA-related genes in a case-control study of 311 gastric cancers and 425 cancer-free controls in a Chinese Han population. RESULTS: We found that two of the SNPs were significantly associated with gastric cancer. Inhibitory effect of minor allele T of rs2071504 SNP within the exon of POLR2A gene was significantly associated with gastric carcinogenesis (p = 0.033, aOR = 0.742, 95%CI = 0.564-0.977) and the SNP rs895819 in the miR-27a gene with the minor allele C presented significantly reduced risk to gastric cancer (p = 0.037, aOR = 0.771, 95%CI = 0.604-0.985). Further stratified analysis with regard to clinical pathological parameters of the patients indicated that the SNP rs2071504 was associated with lymph node metastasis (p = 0.021, aOR = 0.529, 95%CI = 0.307-0.910) and TMN stage (p = 0.021, aOR = 0.532, 95%CI = 0.311-0.908), respectively. CONCLUSIONS: Our findings provided evidence that the SNP rs2071504 in the exon of POLR2A gene would not only confer a decreased risk of gastric cancer, but also influence lymph node metastasis and TMN stage of gastric cancer in the Chinese population.
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| Authors | Yuan Zhou, Wei-Dong Du, Gang Chen, Jian Ruan, Song Xu, Fu-Sheng Zhou, Xian-Bo Zuo, Zhao-Jie Lv, Xue-Jun Zhang |
| Journal | Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 138 Issue 6 Pg. 939-45 (Jun 2012) ISSN: 1432-1335 [Electronic] Germany |
| PMID | 22350505 (Publication Type: Journal Article) |
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