Elevated levels of serum chemerin in patients with obstructive sleep apnea syndrome.
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| Abstract | CONTEXT: Chemerin is implicated to be correlated with obesity and inflammation. OBJECTIVE: This study aims to investigate whether serum chemerin is associated with the presence of obstructive sleep apnea syndrome (OSAS). METHODS: A total of 132 patients with OSAS and 108 healthy subjects were enrolled in this study. RESULTS: Serum chemerin levels were significantly elevated in OSAS patients (120.93 ± 25.84 µg/L vs. 107.51 ± 20.41 µg/L). Multivariable logistic regression analysis revealed that serum chemerin levels were an independent determinant of the presence of OSAS (OR 1.030, 95% CI 1.016-1.045; p < 0.001). Serum chemerin levels in severe OSAS patients were significantly higher compared with those in mild and moderate OSAS patients (p = 0.015 and p = 0.020, respectively). Spearman correlation analysis indicated that serum chemerin levels were correlated with the severity of OSAS (r = 0.210, p = 0.016). Serum chemerin were positively correlated with waist circumference (r = 0.164, p = 0.008), body mass index (r = 0.158, p = 0.014), systolic blood pressure (r = 0.135, p = 0.037), homeostasis model assessment of insulin resistance (r = 0.140, p = 0.031), C-reactive protein (r = 0.202, p = 0.002), and apnea-hypopnea index (r = 0.152, p = 0.022). CONCLUSION: Elevated serum chemerin levels could be an independent predicting marker of the presence and severity of OSAS.
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| Authors | Xuewei Feng, Peng Li, Chuming Zhou, Xi Jia, Jian Kang |
| Journal | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 17 Issue 3 Pg. 248-53 (May 2012) ISSN: 1366-5804 [Electronic] England |
| PMID | 22339491 (Publication Type: Journal Article) |
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