Abstract | BACKGROUND: METHODS: RESULTS:
Nicotine dependence was associated with every examined comorbid psychiatric disorders, with odds ratio varying from 1.75 to 3.33. No evidence supported the associations between the genetic variants and the comorbid disorders (pleiotropy). No evidence suggested that the risks for nicotine dependence associated with the genetic variants vary with comorbid psychiatric disorders in general, but the power was limited in detecting interactions. CONCLUSIONS:
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Authors | Li-Shiun Chen, Hong Xian, Richard A Grucza, Nancy L Saccone, Jen C Wang, Eric O Johnson, Naomi Breslau, Dorothy Hatsukami, Laura J Bierut |
Journal | Drug and alcohol dependence
(Drug Alcohol Depend)
Vol. 123 Suppl 1
Pg. S42-51
(Jun 2012)
ISSN: 1879-0046 [Electronic] Ireland |
PMID | 22336398
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- CHRNA5 protein, human
- Nerve Tissue Proteins
- Receptors, Nicotinic
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Topics |
- Adult
- Comorbidity
- Female
- Genetic Pleiotropy
- Genetic Predisposition to Disease
- Humans
- Logistic Models
- Male
- Mental Disorders
(complications, genetics)
- Middle Aged
- Nerve Tissue Proteins
(genetics)
- Receptors, Nicotinic
(genetics)
- Risk Factors
- Tobacco Use Disorder
(genetics, psychology)
- White People
(genetics)
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