Abstract | BACKGROUND AND STUDY AIMS: Oxidative stress plays an important role in development of intestinal injury after abdomino-pelvic radiation therapy. Teucrium polium (TP) is a medicinal plant which has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effect of TP on radiation-induced intestinal oxidative damage in rats. MATERIALS AND METHODS: Group 1 (n = 8), the control group; Group 2 (n = 8), the RAD (radiation) group in which each rat received a single whole-body 800 cGy radiation performed with a LINAC ; Group 3 (n = 8), the RAD + TP group in which rats were exposed to radiation as in Group 2, followed by intragastric administration of 0.5 g/kg/daily TP extract for 7 consecutive days; and Group 4 (n = 8), the TP group, rats received only intragastric TP for 7 days. RESULTS: CONCLUSIONS: Our results suggest that TP reduces inflammation but does not ameliorate the increased oxidative stress conditions in radiation-induced intestinal damage in rats.
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Authors | U Demirel, M M M Harputluoglu, S B Us, E Kaya, N Sahin, N E Aydin, S Gursoy, Y Bilgic, M Demirel, T Bulut, E B Selcuk, M Aladag |
Journal | Acta gastro-enterologica Belgica
(Acta Gastroenterol Belg)
Vol. 74
Issue 4
Pg. 491-6
(Dec 2011)
ISSN: 1784-3227 [Print] Belgium |
PMID | 22319957
(Publication Type: Journal Article)
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Chemical References |
- Thiobarbituric Acid Reactive Substances
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Topics |
- Animals
- Intestines
(pathology, radiation effects)
- Male
- Oxidative Stress
- Phytotherapy
- Rats
- Rats, Sprague-Dawley
- Teucrium
- Thiobarbituric Acid Reactive Substances
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