A nationwide cohort study on the incidence of meningioma in women using postmenopausal hormone therapy in Finland.
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| Abstract |
The authors conducted a nationwide cohort study to evaluate the association between postmenopausal hormone therapy and meningioma incidence in Finland. All women who had used hormone therapy at least for 6 months at the age of 50 years or older during 1994-2009 were included. Women who had used postmenopausal hormone therapy were identified from the medical reimbursement register of the Social Insurance Institution (131,480 estradiol users and 131,248 estradiol-progestin users), and meningioma cases were identified from the Finnish Cancer Registry. During the average 9 years of follow-up, 289 estradiol users and 196 estradiol-progestin users were diagnosed with meningioma. Ever use of estradiol-only therapy was associated with an increased risk of meningioma (standardized incidence ratio = 1.29, 95% confidence interval: 1.15, 1.44). Among women who had been using estradiol-only therapy for at least 3 years, the incidence of meningioma was 1.40-fold higher (95% confidence interval: 1.18, 1.64; P < 0.001) than in the background population. In contrast, this risk was not increased in users of combination therapy (standardized incidence ratio = 0.93, 95% confidence interval: 0.80, 1.06). There was no difference in risk between continuous and sequential use of hormone therapy. Estradiol-only therapy was accompanied with a slightly increased risk of meningioma.
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| Authors | Katariina Korhonen, Anssi Auvinen, Heli Lyytinen, Olavi Ylikorkala, Eero Pukkala |
| Journal | American journal of epidemiology (Am J Epidemiol) Vol. 175 Issue 4 Pg. 309-14 (Feb 15 2012) ISSN: 1476-6256 [Electronic] United States |
| PMID | 22287638 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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