Lack of pyrogenic tolerance transmission between brain and periphery in the rabbit.

Abstract

Successive injections of lipopolysaccharide (LPS) either intravenously (i.v.) or intracerebroventricularly (i.c.v.) induced pyrogenic tolerance to LPS in rabbits. Tolerance was shown by a decrease of the magnitude of the fever response to repeated doses of LPS, irrespective of the route of pyrogen administration. A significantly greater and more dramatic decrease of the fever index, however, was observed in rabbits made tolerant to pyrogen given i.v. than when the pyrogen was given i.c.v. Transmission of the pyrogenic tolerance between brain and peripheral tissues, however, has not been ascertained.

• Authors: W Kozak, D Soszynski, M Szewczenko, M Bodurka
• Journal: Experientia (Experientia) Vol. 46 Issue 10 Pg. 1010-1 (Oct 15 1990) ISSN: 0014-4754 [Print] Switzerland
• PMID: 2226713 (Publication Type: Journal Article)

Chemical References

• Lipopolysaccharides
• Pyrogens

Topics

• Animals
• Brain (physiopathology)
• Drug Tolerance
• Fever (physiopathology)
• Injections, Intravenous
• Injections, Intraventricular
• Lipopolysaccharides (administration & dosage, pharmacology)
• Male
• Peripheral Nerves (physiopathology)
• Pyrogens (administration & dosage, pharmacology)
• Rabbits