Highly sensitive cardiac troponin T in heart failure: comparison with echocardiographic parameters and natriuretic peptides.

Abstract

BACKGROUND:

Circulating cardiac troponin T is a marker of cardiomyocyte injury, and predicts adverse outcomes in patients with chronic heart failure. However, the significance of highly sensitive cardiac troponin T (hs-TnT) in cardiac dysfunction remains uncertain. The purpose of this study is to evaluate the correlation between hs-TnT and echocardiographic parameters or natriuretic peptides in patients with heart failure.

METHODS AND RESULTS:

We analyzed 283 consecutive out- or in-patients who had B-type natriuretic peptide (BNP) ≥20 pg/mL and were examined by echocardiography (mean age 66.5±13.9 years old; 159 males). Hs-TnT, BNP, N-terminal pro-BNP (NT-proBNP), and creatinine levels were measured simultaneously. LVEDD (left ventricular end-diastolic dimension), LVEF (left ventricular ejection fraction), E', E/E', left ventricular (LV) Tei index, and right ventricular (RV) Tei index were determined with echocardiography. The linear regression analyses demonstrated that loghs-TnT correlated with LVEDD (R=0.242, p<0.0001), LVEF (R=-0.369, p<0.0001), E' (R=-0.447, p<0.0001), E/E' (R=0.364, p<0.0001), LV Tei index (R=0.303, p<0.0001), RV Tei index (R=0.443, p<0.0001), and estimated glomerular filtration rate (eGFR) (R=-0.489, p<0.0001). Using multiple variable regression analysis, loghs-TnT independently correlated with LVEF, E/E', RV Tei index, and eGFR. Furthermore, loghs-TnT significantly correlated with logBNP (R=0.567, p<0.0001) or logNT-proBNP (R=0.647, p<0.0001). Multiple variable regression analysis demonstrated that loghs-TnT independently correlated with logBNP, age, and eGFR, or with logNT-proBNP, age, sex, and eGFR.

CONCLUSIONS:

The hs-TnT correlated with cardiac dysfunction evaluated by echocardiography and natriuretic peptides in patients with heart failure. The elevation of hs-TnT levels in heart failure may represent cardiac dysfunction due to minor and ongoing myocardial injury.

• Authors: Atsushi Kusumoto, Masaaki Miyata, Takuro Kubozono, Yoshiyuki Ikeda, Takuro Shinsato, So Kuwahata, Shoji Fujita, Kunitsugu Takasaki, Toshinori Yuasa, Shuichi Hamasaki, Chuwa Tei
• Journal: Journal of cardiology (J Cardiol) Vol. 59 Issue 2 Pg. 202-8 (Mar 2012) ISSN: 1876-4738 [Electronic] Netherlands
• PMID: 22266455 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• Natriuretic Peptides
• Troponin T
• Natriuretic Peptide, Brain
• Creatinine

Topics

• Aged
• Biomarkers (blood)
• Creatinine (blood)
• Echocardiography
• Female
• Heart Failure (diagnosis)
• Humans
• Male
• Natriuretic Peptide, Brain (blood)
• Natriuretic Peptides (blood)
• Regression Analysis
• Troponin T (blood)