Role of estrogen receptor alpha on vaginal epithelialization of patients with Mayer-Rokitansky-Kuster-Hauser syndrome submitted to neovaginoplasty using oxidized regenerated cellulose.

Abstract

INTRODUCTION AND HYPOTHESIS:

The purpose of this study was to evaluate the expression of estrogen receptor alpha (ERα) on the neovaginal tissue of patients with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome submitted to modified Abbé-McIndoe neovaginoplasty using oxidized regenerated cellulose.

METHODS:

The current study involved eight subjects with MRKH syndrome. Serial samples of the neovagina were obtained after the surgery and immunohistochemical detection of ERα was performed using antibody NCL-L-ER-6F11.

RESULTS:

The operation was performed successfully in all subjects without complications. A total of 22 samples of neovaginal tissue were analyzed. The expression of ERα was detected only 6 months after the surgery, when the neovagina acquired characteristics of normal vagina.

CONCLUSION:

In our study, the expression of ERα occurred when complete epithelialization of vaginal tissue was observed. Other mechanisms may be involved in the formation of vaginal epithelium in patients with MRKH syndrome.

• Authors: Marcio Masashi Kajikawa, Zsuzsanna Ilona Katalin Jármy-Di Bella, Gustavo Rubino de Azevedo Focchi, Juliane Dornelas, Manoel João Batista Castello Girão, Marair Gracio Ferreira Sartori
• Journal: International urogynecology journal (Int Urogynecol J) Vol. 23 Issue 4 Pg. 467-72 (Apr 2012) ISSN: 1433-3023 [Electronic] England
• PMID: 22249275 (Publication Type: Journal Article)

Chemical References

• Cellulose, Oxidized
• Estrogen Receptor alpha
• Estrogens

Topics

• 46, XX Disorders of Sex Development (surgery)
• Abnormalities, Multiple (surgery)
• Adolescent
• Adult
• Biopsy
• Cellulose, Oxidized
• Congenital Abnormalities
• Epithelium (pathology, physiology)
• Estrogen Receptor alpha (physiology)
• Estrogens
• Female
• Gynecologic Surgical Procedures (methods)
• Humans
• Kidney (abnormalities)
• Mullerian Ducts (abnormalities)
• Plastic Surgery Procedures (methods)
• Retrospective Studies
• Somites (abnormalities)
• Spine (abnormalities)
• Treatment Outcome
• Uterus (abnormalities, surgery)
• Vagina (abnormalities, pathology, physiology, surgery)
• Young Adult