Effects of proton pump inhibitors on pediatric inflammatory esophagogastric polyps.

Abstract

BACKGROUND:

The aim of this study was to investigate the effects of proton pump inhibitors on symptomatic inflammatory esophagogastric polyps (IEPs) in a pediatric cohort and to determine the optimal duration of treatment.

METHODS:

The 11 patients with IEPs were managed with lansoprazole. Follow-up endoscopies were performed at 2 and 6 months after the start of medication. Medication was discontinued when the clinical symptoms completely resolved and the polyp size was reduced by more than 50% compared to the initial size.

RESULTS:

The initial polyp size was 13.7 ± 3.3 mm. After 2 months of medication, the polyp size was reduced to 8.0 ± 5.8 mm. At 6 months, the polyp size was 4.7 ± 2.2 mm. The mean duration of medication was 4.8 ± 2.1 months. The duration of medication and the change in the polyp size appeared to have a linear correlation (p < 0.001). According to the formula used to calculate polyp size, the optimal duration of treatment was more than 7 months for complete resolution of the polyps.

CONCLUSIONS:

Proton pump inhibitor was effective for the treatment of IEPs. About 5 months of lansoprazole was adequate to treat IEPs in children. The optimal duration for complete resolution of the polyp might be more than 7 months.

• Authors: Kyong Eun Choi, Mi Jin Kim, Ji Hyuk Lee, Jong Seung Lee, Jee Hyun Lee, Yon Ho Choe
• Journal: Digestion (Digestion) Vol. 85 Issue 3 Pg. 179-84 ( 2012) ISSN: 1421-9867 [Electronic] Switzerland
• PMID: 22248910 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 S. Karger AG, Basel.

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Proton Pump Inhibitors
• Lansoprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles (administration & dosage, adverse effects)
• Adolescent
• Child
• Child, Preschool
• Cohort Studies
• Endoscopy
• Esophageal Diseases (complications, drug therapy, pathology)
• Esophagogastric Junction (pathology)
• Female
• Follow-Up Studies
• Humans
• Lansoprazole
• Male
• Polyps (complications, drug therapy, pathology)
• Prospective Studies
• Proton Pump Inhibitors (administration & dosage, adverse effects)
• Stomach Diseases (complications, drug therapy, pathology)
• Time Factors