Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.

Abstract

We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis. This combination therapy resulted in significant reductions in muscle and skin inflammation, decreased corticosteroid dependence, and halted the progression of calcinosis.

• Authors: Bita Arabshahi, Robert A Silverman, Olcay Y Jones, Lisa G Rider
• Journal: The Journal of pediatrics (J Pediatr) Vol. 160 Issue 3 Pg. 520-2 (Mar 2012) ISSN: 1097-6833 [Electronic] United States
• PMID: 22244459 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Intramural, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright © 2012 Mosby, Inc. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Chelating Agents
• Immunoconjugates
• Immunosuppressive Agents
• Thiosulfates
• Abatacept
• sodium thiosulfate

Topics

• Abatacept
• Adolescent
• Anti-Inflammatory Agents (administration & dosage)
• Antioxidants (administration & dosage)
• Calcinosis (complications)
• Chelating Agents (administration & dosage)
• Dermatomyositis (complications, drug therapy, pathology)
• Drug Therapy, Combination
• Female
• Humans
• Immunoconjugates (administration & dosage)
• Immunosuppressive Agents (administration & dosage)
• Skin Ulcer (complications)
• Thiosulfates (administration & dosage)