Abstract | OBJECTIVE: METHODS: RESULTS: Serum low-density lipoprotein cholesterol levels significantly decreased from 113±38 mg/dl at baseline to 90±20 mg/dl (P=.009) at week 12 of colestimide administration. HbA(1c) significantly decreased from 7.4%±0.9% at baseline to 6.9%±0.9% (P=.001) at week 12 of colestimide administration. Serum 1,5-AG levels increased from 9.4±10.1 μg/ml to 12.4±9.5 μg/ml (P=.05) at week 12 of colestimide administration. The statin group showed no significant changes in lipids and 1,5-AG. However, ΔVFA was inversely correlated with Δcholic acid, and multivariate analysis revealed that ΔVFA was a significant explanatory variable. CONCLUSIONS:
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Authors | Tatsuya Suzuki, Kenzo Oba, Yoshimasa Igari, Kentaro Watanabe, Noriaki Matsumura, Shoko Futami-Suda, Motoshi Ouchi, Kazunari Suzuki, Ken-Ichi Sekimizu, Yoshiaki Kigawa, Hiroshi Nakano |
Journal | Journal of diabetes and its complications
(J Diabetes Complications)
2012 Jan-Feb
Vol. 26
Issue 1
Pg. 34-9
ISSN: 1873-460X [Electronic] United States |
PMID | 22240263
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Anticholesteremic Agents
- Bile Acids and Salts
- Blood Glucose
- Cholesterol, LDL
- Glycated Hemoglobin A
- Imidazoles
- Lipids
- Resins, Synthetic
- colestimide
- hemoglobin A1c protein, human
- Epichlorohydrin
- 1,5-anhydroglucitol
- Deoxyglucose
- Simvastatin
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Topics |
- Aged
- Anticholesteremic Agents
(therapeutic use)
- Asian People
(statistics & numerical data)
- Bile Acids and Salts
(antagonists & inhibitors)
- Blood Glucose
(analysis, drug effects)
- Cholesterol, LDL
(blood)
- Cross-Over Studies
- Deoxyglucose
(blood)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Drug Therapy, Combination
- Epichlorohydrin
(therapeutic use)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Hypercholesterolemia
(blood, drug therapy)
- Imidazoles
(therapeutic use)
- Intra-Abdominal Fat
(drug effects)
- Lipids
(blood)
- Male
- Middle Aged
- Resins, Synthetic
(therapeutic use)
- Simvastatin
(therapeutic use)
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