Cutaneous cytomegalovirus infection in a child with hyper IgE and specific defects in antibody response to protein vaccines.

Abstract

Cytomegalovirus (CMV) infection is a common opportunistic systemic infection in immunocompromised patients, but skin involvement is rare. Herein, we report a 10 year-old girl from consanguineous parents who was referred to our center because of disseminated maculopapular rash. She had history of upper and lower respiratory tract infections. In immunological studies, increased serum IgE level and decreased responses to tetanus and diphtheria were detected. Polymerase chain reaction (PCR) examination of bronchoalveolar lavage and serum sample revealed the presence of CMV. Early diagnosis of cutaneous CMV and appropriate treatment are the key actions in management of patients with underlying immunodeficiencies to avoid further complications.

• Authors: Shahrzad Fallah, Ahmad Tabatabaei, Zahra Pournasir, Zahra Chavoshzadeh, Nima Rezaei
• Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases (Braz J Infect Dis) 2011 Sep-Oct Vol. 15 Issue 5 Pg. 484-5 ISSN: 1678-4391 [Electronic] Brazil
• PMID: 22230858 (Publication Type: Case Reports, Journal Article)

Chemical References

• DNA, Viral
• Immunoglobulin E

Topics

• Child
• Cytomegalovirus (genetics, immunology)
• Cytomegalovirus Infections (diagnosis, immunology)
• DNA, Viral (blood, immunology)
• Female
• Humans
• Immunocompromised Host (immunology)
• Immunoglobulin E (blood)
• Polymerase Chain Reaction
• Skin Diseases, Viral (diagnosis, immunology)