Enhanced activity of linezolid against Staphylococcus aureus in cerebrospinal fluid.

Abstract

Linezolid is considered for treatment of central nervous system (CNS) infections caused by multidrug-resistant Gram-positive bacteria. Therefore, the influence of cerebrospinal fluid (CSF) on the antimicrobial activity of linezolid was evaluated in vitro. Time-kill curves were conducted in CSF and Mueller-Hinton broth (MHB) using Staphylococcus aureus (ATCC 29213) and Staphylococcus epidermidis (ATCC 12228) strains. In CSF lower linezolid concentrations were needed against S. aureus (1× MIC) and S. epidermidis (0.5× MIC) to achieve bacteriostasis than in MHB (4× MIC for both strains). Good activity of linezolid in CSF supports performance of clinical trials evaluating its potential for treatment of CNS infections.

• Authors: Richard Schwameis, Manfred Fille, Mohammad Manafi, Markus Zeitlinger, Robert Sauermann
• Journal: Research in microbiology (Res Microbiol) Vol. 163 Issue 3 Pg. 157-60 (Apr 2012) ISSN: 1769-7123 [Electronic] France
• PMID: 22210435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Acetamides
• Anti-Bacterial Agents
• Oxazolidinones
• Linezolid

Topics

• Acetamides (pharmacology)
• Anti-Bacterial Agents (pharmacology)
• Cerebrospinal Fluid (microbiology)
• Humans
• Linezolid
• Microbial Sensitivity Tests
• Microbial Viability (drug effects)
• Oxazolidinones (pharmacology)
• Staphylococcus aureus (drug effects)
• Staphylococcus epidermidis (drug effects)