Role of uremic toxins and oxidative stress in the development of chronic kidney disease-mineral and bone disorder.

Abstract

The kidney plays an important role in the regulation of mineral metabolism. As kidney function declines, there is a progressive deterioration in mineral homeostasis, along with various abnormalities, including bone disease and vascular calcification, which has recently been named as "Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)." Although the precise mechanisms of this systemic disorder remain to be elucidated, accumulating evidence suggest that uremic toxins contribute substantially to the development of CKD-MBD, partly through evoking oxidative stress in the bone and cardiovascular systems. This brief review summarizes recent work on the role of uremic toxins and oxidative stress in the development of CKD-MBD.

• Authors: Hisae Tanaka, Hirotaka Komaba, Masahiro Koizumi, Takatoshi Kakuta, Masafumi Fukagawa
• Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation (J Ren Nutr) Vol. 22 Issue 1 Pg. 98-101 (Jan 2012) ISSN: 1532-8503 [Electronic] United States
• PMID: 22200424 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Chelating Agents
• Minerals
• Parathyroid Hormone
• Polyamines
• Arginine
• Sevelamer
• pentosidine
• Lysine

Topics

• Arginine (analogs & derivatives, blood, physiology)
• Bone Diseases (etiology)
• Chelating Agents (therapeutic use)
• Homeostasis
• Hyperparathyroidism (complications, drug therapy)
• Kidney Failure, Chronic (etiology, therapy)
• Lysine (analogs & derivatives, blood, physiology)
• Minerals (metabolism)
• Oxidative Stress (physiology)
• Parathyroid Hormone (physiology)
• Polyamines (therapeutic use)
• Renal Dialysis
• Sevelamer
• Uremia (metabolism)
• Vascular Calcification (etiology)