Serum anti-cyclic citrullinated peptide antibodies may predict disease activity in rheumatoid arthritis.

Abstract

To define the relationship between serum anti-cyclic citrullinated peptide antibodies (anti-CCP) and disease activity, and to construct a new disease activity index by using anti-CCP in rheumatoid arthritis (RA). One hundred and five RA patients were included. Disease activity based on DAS28-ESR and serum anti-CCP was measured. There was correlation between serum anti-CCP and DAS28-ESR. (R (2) = 0.71, P value < 0.01). New disease activity index was developed by replacing anti-CCP with ESR in DAS28-ESR. There was correlation between new model and DAS28-ESR. (R (2) = 0.91, P value < 0.01) The new composite index best cut-off values corresponding to DAS28-ESR values of 2.6, 3.2, and 5.1 were 3.21, 3.38, and 4.74, respectively. There was agreement between new model and DAS28-ESR for determination of patients in different disease activity categories. (Kappa = 0.71, P value < 0.01). The new disease activity index that applies serum anti-CCP may predict disease activity in RA.

• Authors: Kamal Esalatmanesh, Raika Jamali, Arsia Jamali, Bardia Jamali, Mohammadreza Nikbakht
• Journal: Rheumatology international (Rheumatol Int) Vol. 32 Issue 12 Pg. 3799-805 (Dec 2012) ISSN: 1437-160X [Electronic] Germany
• PMID: 22187060 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Peptides, Cyclic
• cyclic citrullinated peptide

Topics

• Adult
• Aged
• Arthritis, Rheumatoid (blood, immunology)
• Autoantibodies (blood)
• Cross-Sectional Studies
• Female
• Humans
• Male
• Middle Aged
• Pain Measurement
• Peptides, Cyclic (immunology)
• Predictive Value of Tests
• Severity of Illness Index