Abstract | OBJECTIVE: METHODS: A randomised double-blind study was performed to compare the efficacy of intravenous paracetamol (1 g) and 0.1 mg/kg morphine in patients with renal colic. The efficacy of the study drugs was measured by a visual analogue scale and a verbal rating scale at baseline and after 15 and 30 min. The adverse effects and need for rescue medication (1 μg/kg intravenous fentanyl) were also recorded at the end of the study. RESULTS: 133 patients were eligible for enrolment in the study, with 73 patients included in the final analysis (38 in the paracetamol group and 35 in the morphine group). The mean±SD age of the subjects was 30.2±8.6 years and 51 (70%) were men. The mean reduction in scores at 30 min after study drug administration was 63.7 mm (95% CI 57 to 71) for paracetamol and 56.6 mm (95% CI 48 to 65) for morphine. The difference between pain reduction scores for the two groups at 30 min was 7.1 mm (95% CI -18 to 4), demonstrating no statistical or clinical significance. Two adverse events (5.3%) were recorded in the paracetamol group and five (14.3%) in the morphine group (difference 9%, 95% CI -7% to 26%). CONCLUSION: Intravenous paracetamol is effective in treating patients presenting with renal colic to the emergency department. CLINICAL TRIALS REGISTRATION NO: ClinicalTrials.gov ID number NCT01318187.
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Authors | Mustafa Serinken, Cenker Eken, Ibrahim Turkcuer, Hayri Elicabuk, Emrah Uyanik, Carl H Schultz |
Journal | Emergency medicine journal : EMJ
(Emerg Med J)
Vol. 29
Issue 11
Pg. 902-5
(Nov 2012)
ISSN: 1472-0213 [Electronic] England |
PMID | 22186009
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Analgesics, Opioid
- Acetaminophen
- Morphine
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Topics |
- Acetaminophen
(administration & dosage, adverse effects)
- Adolescent
- Adult
- Analgesics, Non-Narcotic
(administration & dosage, adverse effects)
- Analgesics, Opioid
(administration & dosage, adverse effects)
- Double-Blind Method
- Emergency Service, Hospital
- Female
- Humans
- Injections, Intravenous
- Male
- Middle Aged
- Morphine
(administration & dosage, adverse effects)
- Pain Measurement
- Prospective Studies
- Renal Colic
(drug therapy)
- Young Adult
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