Interleukin-6-producing dermoid cyst associated with multicentric Castleman's disease.

Abstract

Dysregulated overproduction of interleukin-6 (IL-6) from activated B cells in affected lymph nodes has been implicated in the pathogenesis of multicentric Castleman's disease (MCD), a rare lymphoproliferative disorder accompanied by systemic manifestations. We here report the case of a 32-year-old female presenting with MCD associated with a dermoid cyst in the pelvic cavity. The co-occurrence of MCD and dermoid cyst has not been reported before. Immunohistochemical analysis of the tissue sections showed IL-6 production in CD68-positive macrophage cells, which had infiltrated the dermoid cyst. Removal of the cyst resulted in partial improvement in systemic symptoms accompanied by a decrease in serum IL-6, while complete improvement was obtained by treatment with an anti-IL-6 receptor antibody following resection of the dermoid cyst. To the best of our knowledge, this is the first study to provide evidence of IL-6 production by CD68(+) cells in a dermoid cyst involved in MCD.

• Authors: Shigeyuki Ebara, Soken-Nakazawa J Song, Hiroyuki Mizuta, Yasushi Ito, Kenji Hasegawa, Tsuneko Kamata, Teppei Matsumura-Nishikawa, Takafumi Ogawa, Jyunichi Soneda, Kazuyuki Yoshizaki
• Journal: International journal of hematology (Int J Hematol) Vol. 95 Issue 2 Pg. 198-203 (Feb 2012) ISSN: 1865-3774 [Electronic] Japan
• PMID: 22167657 (Publication Type: Case Reports, Journal Article)

Chemical References

• IL6 protein, human
• Interleukin-6

Topics

• Adult
• Biopsy
• Castleman Disease (complications)
• Dermoid Cyst (complications, diagnosis, metabolism)
• Female
• Humans
• Interleukin-6 (blood)
• Pelvic Neoplasms (complications, diagnosis, metabolism)
• Pelvis (diagnostic imaging)
• Tomography, X-Ray Computed