[Effect of Rhaponticum carthamoides extract in combination with dosed physical load on hemorheological parameters of rats with myocardial infarction].

Abstract

The administration of the extract from Rhaponticum carthamoides (150 mg/kg, p.o., for 10 days) in combination with dosed low-power exercise in rats with experimental myocardial infarction led to an improvement of hemorheological indices, which was manifested by a decrease in the whole blood viscosity, aggregation of erythrocytes, and increase in erythrocyte deformability. In particular, the extract from R. carthamoides contributed to an increase in the hematocrit/blood viscosity, which was indicative of an improvement of the blood overall oxygen transport capacity. In addition, administration of the extract in combination with dosed exercise favored normalization of the lactate and pyruvate concentrations in blood of rats with myocardial infarction.

• Authors: M B Plotnikov, A S Vasil'ev, O I Aliev, A M Anishchenko, E A Krasnov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 74 Issue 9 Pg. 7-10 ( 2011) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 22164439 (Publication Type: English Abstract, Journal Article)

Chemical References

• Plant Extracts

Topics

• Animals
• Blood Viscosity (drug effects, physiology)
• Carbohydrate Metabolism (drug effects, physiology)
• Combined Modality Therapy
• Disease Models, Animal
• Exercise Therapy (methods)
• Hemorheology (drug effects, physiology)
• Leuzea (chemistry)
• Male
• Myocardial Infarction (blood, drug therapy, physiopathology)
• Plant Extracts (administration & dosage, isolation & purification, therapeutic use)
• Rats
• Rats, Wistar
• Treatment Outcome