Exposure to maternal overnutrition and a high-fat diet during early postnatal development increases susceptibility to renal and metabolic injury later in life.

Abstract

Overnutrition during pre- and postnatal development both confer increased susceptibility to renal and metabolic risks later in life; however, whether they have an additive effect on the severity of renal and metabolic injury remains unknown. The present study tested the hypothesis that a combination of a pre- and postnatal diet high in fat/fructose would exacerbate renal and metabolic injury in male offspring later in life. Male offspring born to high fat/high-fructose-fed mothers and fed a high-fat/high-fructose diet postnatally (HF-HF) had increased urine albumin excretion (450%), glomerulosclerosis (190%), and tubulointerstitial fibrosis (101%) compared with offspring born to mothers fed a standard diet and fed a standard diet postnatally (NF-NF). No changes in blood pressure or glomerular filtration were observed between any of the treatment groups. The HF-HF offspring weighed ∼23% more than offspring born to mothers fed a high-fat/high-fructose diet and fed a normal diet postnatally (HF-NF), as well as offspring born to mothers fed a standard diet regardless of their postnatal diet. The HF-HF rats also had increased (and more variable) blood glucose levels over 12 wk of being fed a high-fat/high-fructose diet. A combination of exposure to a high-fat/high-fructose diet in utero and postnatally increased plasma insulin levels by 140% compared with NF-NF offspring. Our data suggest that the combined exposure to overnutrition during fetal development and early postnatal development potentiate the susceptibility to renal and metabolic disturbances later in life.

• Authors: Colette M Jackson, Barbara T Alexander, Lauren Roach, Deani Haggerty, David C Marbury, Zachary M Hutchens, Elizabeth R Flynn, Christine Maric-Bilkan
• Journal: American journal of physiology. Renal physiology (Am J Physiol Renal Physiol) Vol. 302 Issue 6 Pg. F774-83 (Mar 15 2012) ISSN: 1522-1466 [Electronic] United States
• PMID: 22160775 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Blood Glucose
• Dietary Fats

Topics

• Aging
• Albuminuria
• Animals
• Blood Glucose
• Body Composition
• Body Weight
• Diet (adverse effects)
• Dietary Fats (adverse effects)
• Female
• Kidney Diseases (etiology, physiopathology)
• Male
• Maternal Nutritional Physiological Phenomena
• Pregnancy
• Prenatal Exposure Delayed Effects (physiopathology)
• Rats
• Rats, Sprague-Dawley