Abstract | PURPOSE: METHODS: We searched the electronic databases MEDLINE, EMBASE, the Cochrane Library, and Google Scholar. Randomized controlled trials comparing auto-CPAP with fixed CPAP were reviewed. Continuous variables were presented as mean difference (MD), and dichotomous data as odds ratio (OR), both with 95% confidence intervals (CI). RESULTS: We identified 19 studies consisting of 845 patients. Compared to fixed CPAP, the use of auto-CPAP reduced mean therapy pressure (MD -1.64; 95% CI -2.46 to -0.82), improved patient compliance (MD 0.23; 95% CI 0.06 to 0.39), increased the percentage of total sleep time (TST) in slow wave sleep (MD 5.11; 95% CI 1.34 to 8.88), and decreased the percentage of TST in stage 2 sleep (MD -4.75; 95% CI -9.38 to -0.11). Moreover, more patients preferred auto-CPAP therapy (OR 3.65; 95% CI 1.27 to 10.53). There were nonsignificant trends towards better outcomes with auto-CPAP for AHI and Epworth Sleepiness Scale (MD -0.43; 95% CI -1.10 to 0.23, and MD -0.24; 95% CI -0.74 to 0.25, respectively), though these are of questionable clinical significance. CONCLUSIONS: There are some aspects of clinical care, such as a mild improvement in compliance, patient preference, and sleep architecture that appear to favor the use of auto-CPAP compared to fixed CPAP. The clinical relevance of these findings requires further study.
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Authors | Ting Xu, Taoping Li, Dongning Wei, Yuan Feng, Lewu Xian, Haiqing Wu, Jian Xu |
Journal | Sleep & breathing = Schlaf & Atmung
(Sleep Breath)
Vol. 16
Issue 4
Pg. 1017-26
(Dec 2012)
ISSN: 1522-1709 [Electronic] Germany |
PMID | 22139138
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review)
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Topics |
- Continuous Positive Airway Pressure
(methods)
- Disorders of Excessive Somnolence
(diagnosis, therapy)
- Humans
- Patient Compliance
- Polysomnography
- Sleep Apnea, Obstructive
(diagnosis, therapy)
- Surveys and Questionnaires
- Therapy, Computer-Assisted
(methods)
- Treatment Outcome
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