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Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.

Abstract
Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.
AuthorsDavid Herrero-Martin, Argyro Fourtouna, Stephan Niedan, Lucia T Riedmann, Raphaela Schwentner, Dave N T Aryee
JournalSarcoma (Sarcoma) Vol. 2011 Pg. 352580 ( 2011) ISSN: 1369-1643 [Electronic] Egypt
PMID22135504 (Publication Type: Journal Article)

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